Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma

Table 3 Increased Treg cell frequency is associated with ICS use and not allergic sensitization

Patient Classification	n	% Treg cells/CD4+ cells (mean, adjusted)	effect*	95%CI	p-value
Children not on ICS	116	6.38	--	--	0.003
Children treated with ICS	39	7.32	0.94	(0.32, 1.55)	0.003
FEIA negative	71	6.76	--	--	0.51
FEIA positive	84	6.94	0.18	(-0.35, 0.71)	0.51
Interaction: P = 0.93

ICS, inhaled corticosteroid; FEIA, fluroenzyme immunoassay; 95% CI, 95% confidence interval.
*difference in LS means in%Treg cells/CD4+ cells between the groups. Four children missing FEIA data were excluded from the analysis.

ISSN: 1476-7961